Mars Needs Mom – $144 million
Disney had the utmost confidence that the sci-fi animation Mars Needs Moms would sweep the box office that they pumped $150 million into its production. The cast consisted of well-known actors like Seth Green and Joan Cusack. However, they did nothing to generate interest in the movie that was doomed from the start.
On its release day, it had the 22nd-worst opening for movies that played in over 3,000 theaters and the 4th-biggest financial loss in history. There was so much focus on technological wizardly in the movie that they forgot to add substance to the storyline. This fatal mistake wound up costing Disney $144 million.