Ice cream
The international symbol for a depressed woman is a female eating straight out of the ice cream, carton. If you walk into a room and your wife is engaged in this activity, then the safest thing to do is to back out slowly, and only go back in if you have cookies.

Approaching a woman eating ice cream like this is very dangerous, as this tweeter has obviously discovered. Asking them what’s wrong is even worse, and you basically deserve whatever banshee-like scream comes your way.