Targeting Dr. Strange
In Captain America: The Winter Soldier, the producers did more than change the very fabric that ties the MCU universe together. In fact, some argue that this film did it a lot more than other movies in the MCU franchise. While interrogating the ex-S.H.I.E.L.D. agent Jasper Sitwell, Captain America, Black Widow, and Falcon forced the Hydra agent to reveal that his organization was about to use three Helicarriers to take out the most cumbersome individuals.
One of the disruptive individuals mentioned by name was Steven Strange. This took place two full years before Dr. Strange scored his own movie.