Raynaud’s Disease
There are just many conditions here on this list that we did not even know that most of them were real things. But Raynaud’s disease is very real and affects the extremities, so hands, feet, and other limbs. It stops those parts from being able to properly regulate heat and deal with the cold.
So every time they are exposed to cold they turn yellow or blue in some cases. It makes for a cool-looking effect like on this person’s hand, but it can lead to some issues if it isn’t taken care of. People who have this always need to make sure that their extremities are taken care of.